Open access
Aug 2026
Reprogramming lineage-traced Müller glia for robust proliferation and neurogenesis in adult mammalian retinas.
The therapeutic potential of adeno-associated virus (AAV)-mediated one-step glia-to-neuron conversion has been challenged following rigorous lineage-tracing analyses. In zebrafish, Müller glia (MG) serve as retinal stem cells to replenish lost neurons after injury. In contrast, mammalian MG do not spontaneously re-ente...
Ye Xie, Ying Xin, Thomas E. Zapadka et al.
· Cell Reports · 0 citations