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Author

J. Quintanilha

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Open access Oct 2026

TP53 Genomic Alterations Including Targetable Y220C Mutation in Advanced Breast Cancer

TP53 Y220C is a rare genomic alteration (GA) with emerging targeted therapies. However, its prevalence in breast cancer remains undefined. We evaluated the prevalence of the Y220C alteration and association with other GAs. A total of 23,760 patients with advanced breast cancer were analyzed by hybrid ca...

N. Casasanta, Adriana M. Kahn, N. Fischbach et al. · 0 citations
Aug 2026

Clinical, genomic, and spatial transcriptomic features of pancreatic adenosquamous carcinoma support subtype-specific therapeutic strategies.

Despite shared genomic drivers with PDAC, ASQ exhibits transcriptionally distinct features with spatially organized tumor and immune heterogeneity, supporting the need for subtype-specific therapeutic strategies.

S. Haldar, Meredith Wetzel, Jia-Yun Lu et al. · 0 citations

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