Review
Open access
Oct 2026
mRNA-based therapies: From molecular discovery to clinical revolution
Abstract For nearly 50 years, scientists have sought to exploit messenger RNA (mRNA) as a therapeutic tool, overcoming major challenges related to instability, delivery, and inflammatory reactions. A major breakthrough came with the incorporation of modified nucleosides, particularly pseudouridine, during in vitro mRNA...
Andressa Peres de Oliveira, Fernanda Sodré, Orlando Louzada-Neto et al.
· Genetics and Molecular Biolo... · 0 citations