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J. R. Victor

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Review Open access Sep 2026

Hooks without bait: IgG repertoire–mediated immune regulation across immune development and ageing

Immunoglobulin G (IgG) changes across the life course as B-cell selection, antigenic experience, inflammation, class switching, somatic diversification, and Fc glycosylation evolve. The ‘hooks without bait’ hypothesis proposes that idiotype/variable-region determinants within a polyclonal IgG repertoire can recog...

J. R. Victor · 0 citations

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