Hooks without bait: IgG repertoire–mediated immune regulation across immune development and ageing
Immunoglobulin G (IgG) changes across the life course as B-cell selection, antigenic experience, inflammation, class switching, somatic diversification, and Fc glycosylation evolve. The ‘hooks without bait’ hypothesis proposes that idiotype/variable-region determinants within a polyclonal IgG repertoire can recog...