Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and exhibit temporal covariation, demanding a...
Wei Wu, Gen Li, Kai Wang et al.· Nature Computational Science· 2 citations
Th17 cells are central drivers of autoimmune pathology, including multiple sclerosis (MS), yet the endogenous metabolic signals that shape their pathogenic differentiation remain incompletely defined. Prostaglandin D₂ (PGD2) is traditionally viewed as an extracellular mediator in allergic diseases. Here, we identify PG...
Yu-Xin Zhuang, Kawai Lei, Yan Li et al.· Signal Transduction and Targ...· 0 citations
Oncoformer provides a framework for risk-informed cancer prediction and treatment stratification using routine clinical data and was independently validated against postoperative pathological endpoints and shown to converge on core cancer genomic pathways.
Fei Liu, Kai Wang, Hui Xu et al.· Cell· 2 citations
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