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J. Rasko

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Open access Aug 2026

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and exhibit temporal covariation, demanding a...

Wei Wu, Gen Li, Kai Wang et al. · 2 citations
Open access Oct 2026

Targeting the HPGDS-PGD2 axis to treat Th17 cell-mediated autoimmunity in multiple sclerosis

Th17 cells are central drivers of autoimmune pathology, including multiple sclerosis (MS), yet the endogenous metabolic signals that shape their pathogenic differentiation remain incompletely defined. Prostaglandin D₂ (PGD2) is traditionally viewed as an extracellular mediator in allergic diseases. Here, we identify PG...

Yu-Xin Zhuang, Kawai Lei, Yan Li et al. · 0 citations
Open access Jul 2026

Advancing cancer detection and treatment using longitudinal routine clinical data.

Oncoformer provides a framework for risk-informed cancer prediction and treatment stratification using routine clinical data and was independently validated against postoperative pathological endpoints and shown to converge on core cancer genomic pathways.

Fei Liu, Kai Wang, Hui Xu et al. · 2 citations

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