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Open access Sep 2026

Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study.

BACKGROUND As individuals with Down syndrome age, they face high risks of Alzheimer's disease and epilepsy. With symptomatic Alzheimer's disease, late-onset myoclonic epilepsy in Down syndrome (LOMEDS) often emerges. We aimed to examine how epilepsy develops in Down syndrome, its timing relative to Alzheimer's disease...

Lucía Maure-Blesa, M. Carmona-Iragui, I. Barroeta et al. · 1 citation
Open access Sep 2026

Tear fluid CGRP changes in epilepsy - evidence from an exploratory pilot study.

BACKGROUND AND OBJECTIVES Epilepsy and migraine share pathophysiological and clinical features. While calcitonin gene-related peptide (CGRP) is a central player in migraine pathophysiology, it has also been identified in cortical neurons, making CGRP a plausible modulator of cortical excitability. This exploratory tria...

Cem Thunstedt, S. Trapp, K. Kamm et al. · 0 citations

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