Author

J. Rey

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Open access Sep 2026

MxB N-Terminus Adopts a Stable α-Helix to Engage the HIV-1 Capsid Trimer Interface

The HIV-1 capsid, composed of capsid (CA) proteins arranged into a conical surface lattice, serves as a critical platform for host–pathogen interactions. Many host cofactors regulate HIV-1 infection by selectively recognizing the higher-order CA lattice rather than individual monomers or capsomers. Among these, Myxovir...

Ya-Nan Zhu, J. Rey, Juan Shen et al. · bioRxiv · 0 citations

Open access Aug 2026

Stoichiometric Binding of Cyclophilin-A to The HIV-1 Capsid Modulates Its Mechanoelastic Properties.

Protein nanocapsules balance structural rigidity with mechanical deformability to perform their biological functions. The HIV-1 capsid, a ∼ 120 nm conical shell assembled from over 1000 capsid protein (CA) subunits, exemplifies this challenge: it must be stable to protect the viral cargo while remaining sufficiently de...

J. Rey, Alexander J. Bryer, J. Perilla · Small · 0 citations