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OBJECTIVE Lennox-Gastaut syndrome (LGS) is a severe childhood onset epilepsy marked by drug-resistant seizures and generalized electroencephalographic abnormalities. Because patient-reported seizures are often unreliable, objective biomarkers are needed. This study investigates circadian modulation of aperiodic and osc...
ObjectiveThe current International League Against Epilepsy (ILAE) guidelines for Lennox-Gastaut syndrome (LGS) mandate the presence of generalized paroxysmal fast activity (GPFA) on EEG. However, GPFA is not necessarily restricted to LGS and has been described in, among others, idiopathic generalized epilepsies. A clea...
The results expand and refine the understanding of the thalamus as a region showing robust and recurrent associations across multiple clinical conditions of TLE and distinguish its role in pre- versus postsurgical brain organization with respect to seizure and neuropsychological outcomes.
Real-world decision-making rarely occurs with perfect information. Instead, individuals must constantly weigh potential rewards against the probability of adverse outcomes.1 Failures of this process can lead to maladaptive decisions associated with reduced lifetime success, and numerous psychiatric disorders such as ga...
In a climate of growing delays in epilepsy care, there did not observe differences in RNS efficacy with or without prior sEEG monitoring in patients with unilateral or bilateral temporal lobe epilepsy, temporal-plus epilepsy, and extratemporal epilepsy.
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