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Aug 2026

Molecular Alterations in Patients of Color with Advanced Cutaneous and Unknown Primary Melanomas.

BACKGROUND Cutaneous melanoma is rare in Patients of Color (POC), and the genomics are not well understood. OBJECTIVE Describe MAPK drivers and tumor mutational burden (TMB) of cutaneous and unknown primary (CUP) melanoma in POC and compare them to non-Hispanic White (NHW) patients. METHODS We analyzed a retrospect...

J. Ross, Vanessa R. Weir, Leore Lavin et al. · 0 citations
Aug 2026

A Phase 2 Basket Trial of Ado-Trastuzumab Emtansine for Patients with HER2 Amplified Cancers: A Non-Randomized Clinical Trial.

PURPOSE To evaluate the efficacy of ado-trastuzumab emtansine (T-DM1) among patients with advanced/metastatic HER2-amplified solid tumors. PATIENTS AND METHODS This was a single-center, non-randomized phase 2 basket trial conducted at Memorial Sloan Kettering Cancer Center. All 95 patients had HER2-amplified metastat...

J. Ross, W. Wong, Lauren Schoech et al. · 0 citations
Review Sep 2026

The changing therapeutic landscape of small-cell lung cancer.

Small-cell lung cancer (SCLC) is an exceptionally aggressive malignancy: highly proliferative, heterogeneous, and frequently metastatic at diagnosis. Although initially responsive to chemotherapy, such responses are typically transient, and recurrent disease has been largely refractory to standard cytotoxics. The past...

J. Ross, K. Hockemeyer, E. Redin et al. · 2 citations

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