Author

J. Schrader

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Open access Jun 2025

Bacterial ribonucleoprotein bodies maintain an acidic pH environment as a mechanism of enzyme regulation

Phase separated biomolecular condensates create subcellular niches, yet their role in client regulation remains unclear. Here, we demonstrate that Bacterial Ribonucleoprotein bodies (BR-bodies) are acidic. Using ratiometric fluorescent probes in vivo, we find BR-bodies exhibit a dense-phase pH of ∼5.1, significantly lo...

Wade E. Schnorr, Moeka Sasazawa, Kathryn G. Dzurik et al. · bioRxiv · 0 citations

Open access Jul 2026

BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in Brucella

Brucella, an intracellular bacterial pathogen and causative agent of the disease brucellosis, relies on biomolecular condensates called bacterial ribonucleoprotein bodies (BR-bodies) to control RNA stability and regulate gene expression, providing evidence that phase separation is a fundamental mechanism underlying Bru...

K. S. Mallikaarachchi, Rosemary Northcote, Thomas Kim et al. · bioRxiv · 1 citation