Author

J. Schulte-Schrepping

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Open access Aug 2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence

DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...

Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al. · Nature Neuroscience · 1 citation

Open access Aug 2026

Memory T Cells in MHC-Deficient Humanized Mice

This work investigated how elimination of murine MHC together with different conditioning regimens shapes human T-cell maturation in vivo, and revealed marked differences in T-cell differentiation across models.

M. Darguzyte, Ж. Ш. Жумадилова, F. Khan et al. · bioRxiv · 0 citations

Open access Aug 2026

Perturb-seq identifies co-regulated gene programs shaping hematopoietic stem and progenitor cell function

Perturbation-derived co-regulation programs are established as an interpretable framework for linking genetic regulators, cell-biological processes and stem-cell-associated phenotypes by decomposing gene expression data from functional and clinical studies into program activity.

Joseph S. Bowness, Aina Bernal Martínez, Jan Bařinka et al. · bioRxiv · 0 citations