Manual expert gating remains common practice for defining specific cell populations in flow cytometry data, but increasing numbers of measured parameters and high inter-rater variability limit consistency across studies. Cluster-based approaches use the full marker space to define cell populations more consistently, bu...
V. Friedrich, Karola Mai, T. Hofer et al.· Nature Communications· 0 citations
DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...
Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al.· Nature Neuroscience· 1 citation
A reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and enabling the study of Alzheimer’s disease-relevant perturbations and drug responses is developed.
Julien Klimmt, Carolina Cardoso Gonçalves, J. V. Montgomery et al.· Nature Neuroscience· 1 citation
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