Author

J. Siveke

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Open access Sep 2026

Real-world survival benefit of adding durvalumab to chemotherapy in cholangiocarcinoma: a retrospective cohort analysis from a German Comprehensive Cancer Centre

Background Advanced biliary tract cancers (BTCs) carry a poor prognosis. Gemcitabine/platinum chemotherapy was the first-line standard until TOPAZ-1 and KEYNOTE-966 established immune checkpoint inhibitor-based combinations as a new standard. Real-world data with a chemotherapy-only comparator remain limited. Patients...

S. Elbasan, S. Kasper, I. Mavroeidi et al. · ESMO real world data and dig... · 0 citations

Open access Jul 2026

An explainable transformer model learning from entire treatment timelines for pan-cancer risk profiling across healthcare systems

Chronicle is introduced, an explainable transformer that learns from entire patient trajectories, predicts diverse clinical outcomes throughout the disease course while capturing both short- and long-term temporal dependencies, providing a scalable framework to support individualized treatment decisions.

P. Keyl, N. Kiermeyer, J. Bosserhoff et al. · medRxiv · 0 citations