J. Soucy

Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer’s disease

Lower static connectivity across multiple large-scale networks was associated with faster longitudinal tau accumulation and, selectively in individuals with elevated amyloid burden, with accelerated cognitive decline, and these associations were not observed for time-varying connectivity.

HIPPOCAMPAL TAU-RELATED SIGNAL INDEXES HYPEREXCITABILITY AND NREM SLEEP–MEMORY DYSFUNCTION IN TEMPORAL LOBE EPILEPSY

Differential associations of tau extent and load with brain metabolic and cognitive dysfunction in Alzheimer's disease

Summary Background Reduced [18F]Fluorodeoxyglucose ([18F]FDG)-PET uptake is a core imaging feature of Alzheimer's disease (AD). While tau load correlates with this metabolic signature, it remains unclear whether the spatial extent of tauopathy (SEOT) more accurately explains brain glucose hypometabolic patterns. Here,...