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J. Spieser

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Open access Sep 2026

Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in GNAS (Gαs) mutant pancreas cancer

Maintenance of fissed mitochondria is viewed as a defining feature of Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant cancers. However, regulation of this process by accompanying comutations or environmental factors is not clearly defined. Here, by analyzing a subset of pancreatic cancer lesions driven by conc...

Grant A. Hagedorn, J. Spieser, N. Hirai et al. · 0 citations

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