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Open access Sep 2026

Structural basis of ligand-selective transcriptional activation in the MerR-family antibiotic resistance regulator AlbA

Multidrug-resistant pathogens demand novel resistance-breaking strategies. The oligoarylamide albicidin and pyrrolobenzodiazepines (PBDs) are potent antibacterials with unrelated scaffolds, yet both are neutralized by albA gene products in many Gram-negatives: AlbA, an albicidin-responsive self-upregulating MerR-family...

M. Di Palma, A. Grinzato, P. Andriollo et al. · 0 citations
Open access Aug 2026

A liquid handling platform for standardized quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes

A semi-automated workflow using cell-free gene expression systems to measure the activity of two ARGs encoded on plasmid DNA that produce rifampicin-inactivating and gentamicin-inactivating enzymes offers a strategy to combat AMR.

Molly Bergum, Sahana Suthakaran, Bethany Martin et al. · 0 citations

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