Author

J. Tegnér

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Open access Jul 2026

Unify learns cellular evolution with universal multimodal embeddings

Integrating single-cell RNA-sequencing (scRNA-seq) data across species is hindered by evolutionary divergence, technical batch effects, and the reliance on one-to-one orthologs. Here, we present Unify, a transfer learning methodology that learns universal cell embeddings by defining functionally coherent, multi-modal m...

Hua-Wen Zhong, Wenkai Han, Guoxin Cui et al. · Nature Communications · 0 citations

Open access Aug 2026

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosis

Despite immune-cell infiltration being a hallmark of multiple sclerosis (MS), the interplay between the periphery and central nervous system immune responses is still incompletely characterized. We performed single-cell transcriptomic and V(D)J sequencing of paired blood and cerebrospinal fluid (CSF) immune cells from...

Nils Hallén, S. J. Fernandes, S. Rad Pour et al. · bioRxiv · 0 citations

Open access Aug 2026

The human RNA-DNA interactome is cell type-specific and dynamic

The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.

A. Lambolez, P. Sahlén, Wenjing Kang et al. · bioRxiv · 0 citations