Open access
Sep 2026
CDKL5 deficiency impairs TBK1-mediated autophagy and clearance of neuronal protein aggregates
A CDKL5/SINTBAD/TBK1 signaling axis that couples proteotoxic stress to activation of selective autophagy receptors is defined and impaired proteostasis is identified as a previously unrecognized consequence of CDKL5 deficiency.
Zhongju Zou, B. Kahn, Salwa Sebti et al.
· bioRxiv · 0 citations