Tumor progression is driven by cancer cells’ ability to establish a cellular network through tunneling nanotube-like connections (TNTs), which enable mitochondrial exchange both within the tumor cells and with the tumor microenvironment (TME). However, the functional consequences of mitochondrial transfer between tumor...
Inés Saénz-de-Santa-María, Anna Pepe, J. Tinevez et al.· Nature Communications· 0 citations
Bacterial proliferation in confined spaces occurs in biofilms, intracellular compartments, or infection sites, generating mechanical constraints. We investigated how growth-induced mechanical pressure affects bacterial physiology using a microfluidic device ensuring nutrient access. We found that proliferating Escheric...
Laure Le Blanc, Baptiste Alric, Romain Rollin et al.· Nature Communications· 0 citations
Capsid stabilization, induced by low-nanomolar concentrations of Lenacapavir (LEN)—a first-in-class capsid inhibitor—impedes HIV-1 replication in macrophages without disrupting reverse transcription or nuclear import. In LEN-treated cells, ultrastructural analyses reveal preserved conical capsids persisting within nucl...
Thierry Mourer, M. Harastani, Celine Cuche et al.· Science Advances· 0 citations
Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously showed that choanoflagellates, the closest living relatives of animals and classically viewed as obligate flagellated swimm...
Maite Freire-Delgado, Diede de Haan, Stéphane Tachon et al.· bioRxiv· 0 citations
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