J. V. D. van der Hooft

Metabolite co-variation networks reveal keystone functions and an emergent pathogen state in the human urobiome

PhenoRewire, a network-based framework that quantifies how metabolite co-variation is rewired between biological states using untargeted metabolomics data, is developed and applied to an induced pluripotent stem cell (iPSC) urothelial organoid-derived barrier co-cultured with synthetic urobiome communities as a model o...