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J. van de Wijgert

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Review Open access Oct 2026

Role of the urobiome in urinary tract infections: current knowledge and research prospects.

Urinary tract infections (UTIs), particularly cystitis, are among the most common bacterial infections worldwide, with a disproportionate burden on adult female individuals, who often have recurrence. The discovery of the urobiome, a low microbial biomass community in the urinary tract, has transformed our understandin...

Marleen D. Hekker, Adam J. Bindas, Freya Darling Eriksen et al. · 0 citations
Open access Aug 2026

An expanded urine culturing workflow to cultivate and characterize diverse urobiome isolates

Background Despite increased recognition of the urinary tract’s diverse resident microbiome (i.e., the urobiome) in postmenopausal women, the roles and functions of these microbes remain largely unknown. Further empirical research is needed to understand the physiology, interactions, and antibiotic resistance evolution...

Freya Darling Eriksen, Marleen D. Hekker, Corné van der Zeeuw et al. · 1 citation
Open access Jul 2026

Salivary polyreactive and SARS-CoV-2-specific antibody responses following SARS-CoV-2 infection and vaccination in healthcare workers.

SARS-CoV-2 infection, but not vaccination, induces distinct changes in the salivary IgA compartment, including polyreactive antibodies, which may reflect repeated mucosal immune stimulation and is associated with greater symptom burden.

Mischa H. Koenen, Juana Claus, Myrthe E Reiche et al. · 0 citations

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