Author

J. van der Oost

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Open access Sep 2026

Size and sequence variation of the Lid of the Cas12a nuclease domain results in a nickase phenotype

Abstract CRISPR–Cas12a nucleases typically induce double-strand breaks (DSBs) to initiate genome editing. However, reliance on DSBs risks chromosomal rearrangements and unintended insertions or deletions at off-target sites. Therefore, engineering nickase variants that cleave only a single DNA strand might enable preci...

Ricardo Villegas Warren, Satoshi N. Omura, Diana León-Castro et al. · Nucleic Acids Research · 0 citations

Open access Jul 2026

Systematic engineering and machine learning analysis of intrinsic terminators reveal crucial nucleotides directly upstream of the terminator hairpin

This study showed that an additional adenosine nucleotide upstream of the terminator hairpin leads to improved protein production while reducing terminator read-through, revealing an important role for the nucleotides directly upstream of the terminator hairpin.

Charlotte C. Koster, B. Terlouw, Thijs Nieuwkoop et al. · bioRxiv · 0 citations

Open access Aug 2026

Elucidating biosynthetic pathways related to the synthesis of small halogenated peptidic natural products in marine sponge microbiomes

The present work queried metagenomes of several sponge species by making use of a minimal set of core enzymes that postulate to be necessary to produce small peptidic NPs, revealing a variety of novel BGC architectures, many of which showed conservation among sponge host phylogenies and were encoded in the genomes of d...

Catarina Loureiro, M. Schorn, Mohammad M. Alanjary et al. · bioRxiv · 0 citations