Testosterone Replacement Therapy in Adolescents and Young Adults With Prader-Willi Syndrome: Efficacy and Effects on Behaviour.
CONTEXT Hypogonadism in Prader-Willi syndrome (PWS) is associated with decreased bone mineral density (BMD) in male adolescents and adults. Testosterone Replacement Therapy (TRT) improves BMD and sexual maturation, but TRT could aggravate pre-existing challenging behaviour in male patients with PWS. OBJECTIVE To inve...