To evaluate whether preoperative serum interleukin-6 (IL-6) is associated with severe postoperative complications after colorectal cancer resection.
This retrospective analysis included 474 patients undergoing curative-intent colorectal cancer resection at Oulu University Hospital between 2010 and 2020. Pr...
P. Peroja, Jukka M. Rintala, A. Tuomisto et al.· International Journal of Col...· 0 citations
The RNF43 p.G659fs (RNF43659mut) mutation occurs in 8% of colorectal cancers (CRCs) and is enriched in microsatellite instability–high (MSI-H) tumors. Although RNF43659mut promotes tumor growth through phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) activation independent...
Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel et al.· Science Advances· 0 citations
Colon cancer is a major global malignancy with significant mortality. Right-sided (RCC) and left-sided colon cancers (LCC) exhibit distinct clinicopathological characteristics. Tumor microenvironment score (TMS) combines Klintrup-Mäkinen grade, tumor stroma percentage, and tumor budding, classifying cases into 4 groups...
Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä et al.· American Journal of Surgical...· 0 citations
Findings highlight the utility of PDTOs for studying tumor-intrinsic mechanisms of treatment response and identify EPSTI1 as an epithelial modulator of chemosensitivity.
E. Erkan, Emmi Hämäläinen, Julia Kolikova et al.· Oncogene· 0 citations
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