Author

J. Veening

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Open access Sep 2026

Type I restriction–modification systems regulate gene expression through DNA topology

Abstract This study examines how DNA methylation by both phase-variable and canonical restriction–modification (RM) systems contributes to bacterial gene regulation, using the SpnD39III system of Streptococcus pneumoniae and the prototypical EcoKI system of Escherichia coli. RNA-seq analysis of pneumococcal phase-locke...

Yasmeen Althari, Yong-Kui Chen, A. Menon et al. · Nucleic Acids Research · 0 citations

Open access Sep 2026

Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ.

The arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multidrug-resistant bacterial pathogens. However, the large amount of genes of unknown function in phage genomes remains a major obstac...

Dorentina Humolli, Damien Piel, J. Ransome et al. · Nature Microbiology · 2 citations

Open access Aug 2026

Monounsaturated fatty acid biosynthesis is critical for streptococcal envelope homeostasis and stress tolerance

The role of de novo monounsaturated fatty acid (MUFA) synthesis in physiology and virulence-associated traits was examined in Streptococcus mutans, Streptococcus pyogenes, and Streptococcus pneumoniae, three major pathogens that cause disease at distinct body sites.

J. L. Baker, Jonah Tang, Mingzhe Guo et al. · Journal of Bacteriology · 0 citations