Author

J. Vöglein

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Open access Oct 2026

Network‐dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease

Abstract BACKGROUND Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau‐harboring epicenters. METHODS One hundred thirty‐one amyloid‐posit...

Lukas Frontzkowski, Sebastian N. Roemer-Cassiano, Johannes S. Gnörich et al. · Alzheimer's & Dementia · 0 citations

Open access Sep 2026

Longitudinal Dynamics of the Blood Proteome Within the Alzheimer Spectrum in Down Syndrome

Background and Objectives Adults with Down syndrome (DS) have an increased risk of developing early Alzheimer disease. While our previous cross-sectional study investigated the blood proteome in the context of Alzheimer in DS, identifying CBLN4, CD14, C-X-C motif chemokine 17 (CXCL17), ectodysplasin A2 receptor (EDA2R)...

Olivia Wagemann, Georg S. Nuebling, K. Sandkühler et al. · Neurology · 0 citations