Mitochondrial diseases exhibit heterogeneous pathophysiologies and phenotypes that, depending on severity, may substantially impair health, development, and life quality. This heterogeneity makes accurate disease-speci fi c treatment indispensable. This applies in particular to MEGDEL syndrome (associated with mutations...
Philipp Köberle, F. Lange, Ghadir Abbas et al.· Movement Disorders Clinical...· 0 citations
Background There is substantial overlap in the perceived clinical presentation of essential tremor (ET) and dystonic tremor (DT). As both etiologies require different treatment approaches, establishing the correct clinical diagnosis remains key. Massive time series feature extraction and machine learning allows the exa...
V. Selzam, V. Häring, J. F. Martin-Rodriguez et al.· Frontiers in Neurology· 0 citations
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been explored to treat gait disturbances. However, clinical outcomes of MLR-DBS have been disappointing overall, with only modest benefits in some individuals and unwanted effects, including anxiety, reported in others. Preclinical studies in...
Martina Wilhelm, J. Hartig, Teresa Christina Faupel et al.· bioRxiv· 0 citations
Subthalamic nucleus–deep brain stimulation (STN–DBS) reliably improves cardinal motor symptoms in Parkinson's disease (PD). However, gait disorders and non-motor symptoms (NMS) may persist or emerge following surgery, diminishing quality of life and complicating clinical management. To characterize the dominant axes of...
Ghadir Abbas, Robert Peach, U. Temuulen et al.· Journal of Neurology· 0 citations
Summary Background Patient-facing medical AI chatbots are entering clinical use faster than evidence can characterise their real-world safety. We evaluated one deployed system and introduce CARE-LLM, a proposed framework for conversation-level post-market surveillance. Methods We conducted a prospective, observational,...
Florian Lange, Ssaman Mardi, T. Binder et al.· The Lancet Regional Health -...· 0 citations
It is shown that the mouse VNC feeds extensive Vglut2-defined projections into striato-thalamo-subthalamic and caudal medulla motor hubs and receives substantial input from the sensorimotor cortex and receives substantial input from the sensorimotor cortex.
J. Hartig, M. Friedrich, J. Signoret-Genest et al.· Nature Communications· 0 citations
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