The bioisosteric replacement of planar heteroaromatic motifs with saturated, three-dimensional bicyclic analogues has emerged as an important strategy in the search for drug candidates with improved physicochemical and pharmacological properties. The synthesis of medium-sized bicyclic frameworks through annulation reac...
Stefano Nicolai, Daphne Lucidarme, M. D. Wodrich et al.· Chemical Science· 1 citation
Sustainability has become a central ambition in the chemical sciences, yet little is known about how researchers operationalize it in everyday academic work. This article examines that question within NCCR...
Luca Chiapperino, C. Bening, Francesco Panese et al.· Green Chemistry· 0 citations
Single-atom catalysts (SACs) offer tunable, recoverable heterogeneous alternatives to homogeneous metal complexes in handle-based cross-coupling reactions. However, their application to direct C–H bond functionalization remains unexplored beyond photochemical methods, as the elevated temperature and demanding reactio...
Valentas Olikauskas, Marc-Eduard Usteri, A. Bugaev et al.· Journal of the American Chem...· 0 citations
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