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J. Weigele

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Open access Sep 2026

Mitofusin Activation Delays Aging in Caenorhabditis elegans

Age-linked tissue dysfunction is associated with mitochondrial degeneration manifested as organelle fragmentation and respiratory dysfunction. Efforts to mitigate downstream consequences of mitochondrial degeneration, as with ROS scavengers, have not translated to the human condition. We posit that intrinsic fusion-med...

J. Weigele, Li-Hong Zhang, Jia-Jia Li et al. · 0 citations
Open access Aug 2026

Neuromuscular Dysfunction and Charcot-Marie-Tooth Disease Reversal in Mfn2 T105M Knock-In Rats

Unprecedented utility of the Mfn2 T105M rat as a model of CMT2A is demonstrated, the menu of clinically applicable tests that may have use in future human trials are expanded, and a strong foundation for exploration of extra-neuronal consequences of pathogenic mitofusin variants in non-mouse models is established.

J. Weigele, A. Franco, Gerald W. Dorn · 0 citations

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