Author

J. Wietrzyk

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Open access Aug 2026

Priming Cells with Modulators of Cellular Signaling Ensures Enhanced Selectivity of HSPG-Specific Protein–Drug Conjugate Delivery

TriFHS-MMAE is reported, the first multivalent PDC specifically targeting heparan sulfate proteoglycans overexpressed by pancreatic cancer cells, which induces ultrafast and highly efficient aggregation-dependent endocytosis (ADE) of HSPGs.

Aleksandra Chorążewska, Krzysztof Ciura, M. Milczarek et al. · Journal of the American Chem... · 0 citations