Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed. We analysed s...
S. Abu-Rumeileh, H. Großkopf, Arthur Guthknecht et al.· Nature Communications· 0 citations
The role of physical fitness in cognitive reserve and brain maintenance remains unclear. We investigated the associations of muscular and aerobic fitness (VO2max) with markers of brain health and cognition in 353 cognitively unimpaired older adults (mean age = 72.77 ± 7.95 years; 177 females). Muscular fitness compris...
S. Schwarck, N. Behrenbruch, B. Schumann-Werner et al.· npj Aging· 0 citations
Introduction Diagnosis of frontotemporal lobar degeneration (FTLD) is complicated by high heterogeneity within diagnostic groups and overlap between them. Using an unsupervised machine learning technique this study aimed to increase understanding of neuropsychological profiles in the spectrum of FTLD syndromes and to a...
Marie Söntgerath, S. Cutini, A. Thöne-Otto et al.· Frontiers in dementia· 0 citations
Differential associations of age and AD pathology with mesoscale MTL-connectivity patterns show differential associations of age and AD pathology with mesoscale MTL-connectivity patterns, which may support memory function in the short term while contributing to subsequent memory decline.
Larissa Fischer, N. Vockert, Joseph Höpker Fernandes et al.· bioRxiv· 0 citations
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