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Five decades of pneumococcal meningitis in Spain: a single-centre, clinical and genomic, retrospective, observational study.
BACKGROUND Pneumococcal meningitis remains a major threat, with high fatality rates and long-term sequelae, despite advances in vaccination and treatment. We aimed to examine the associations between pneumococcal serotypes, Global Pneumococcal Sequence Cluster (GPSC), antimicrobial resistance, source of infection, and...
Antibacterial and Antibiofilm Activity of Aspergillus-Derived Gliotoxin Against Streptococcus pneumoniae and Staphylococcus aureus: Interaction with Conventional Antibiotics
Antimicrobial resistance and the formation of biofilms in Gram-positive pathogens such as Streptococcus pneumoniae and Staphylococcus aureus are making the treatment of infections increasingly difficult. This study systematically evaluates the effect of gliotoxin (GT), an antimicrobial metabolite produced by Aspergillu...