Heart failure with preserved ejection fraction (HFpEF) represents a predominant heart failure phenotype characterized by intricate pathophysiology and an escalating global prevalence. Beyond classical hemodynamic disturbances, emerging evidence identifies mitochondrial dysfunction as a central mechanism in HFpEF pathog...
Ying An, Cong-Hui Shang, A. M. Abd el-Aty et al.· The Journal of Cardiovascula...· 0 citations
S-HFD is associated with gut dysbiosis and steatohepatitis-like features, highlighting the importance of fat sources in shaping microbiome-host interactions in metabolic disease.
F. Bahman, M. Z. Malik, S. Kochumon et al.· Frontiers in Nutrition· 0 citations
Together, the results reveal dysregulation in pathways in muscle tissue from individuals with diabetes, identify candidate drivers, and connect the genomic drivers of this dysregulation across type 2 diabetes and related metabolic traits.
A. Maddox, Nandini Manickam, Peter Orchard et al.· bioRxiv· 0 citations
It is suggested that sucrose elimination from a low-fat diet disrupts gut microbiota, impairs metabolic homeostasis, and promotes gut and liver inflammation, revealing an unrecognized dietary trigger of metabolic dysfunction.
N. Almansour, S. Kochumon, Fatema Al-Rashed et al.· Frontiers in Immunology· 0 citations
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