Selective Segregation of Damaged Molecules Is the Universal Rule of Cellular Rejuvenation, and Centriolar Retention in Stem Cells Is Its Exception
The hypothesis that centrioles function as division counters in replicative aging predicts that aging driven by centriolar damage requires (i) a population of dividing cells whose centrioles are propagated through mitosis and (ii) a somatic self-renewal system in which such propagation persists. Adult Caenorhabditis el...