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Author

Jack A. Bibby

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Jul 2026

Sp1 links CD46 to CD4 T cell metabolic fitness, survival, and retroviral control.

It is shown that the CD46 signaling domain cytoplasmic tail 1 (CYT-1) engages the transcription factor Sp1 in human CD4 T cells to dynamically modulate Sp1-DNA interactions, defining a human-specific transcriptional mechanism linking complement signaling to metabolic adaptation, apoptosis regulation, and antiviral defe...

Parul Singh, Luopin Wang, Pavitra Ramdas et al. · 0 citations
Open access Jul 2026

Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease 2309676

A previously unrecognized CPM-dependent mechanism that balances C5aR1 and C5aR2 signaling to limit pathological T cell activation is uncovered, revealing an intrinsic complement-driven checkpoint that constrains effector T cell immunity.

Erin E. West, Nicolas S. Merle, Ayden Case et al. · 0 citations

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