Author

Jacob E. Corn

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Open access Aug 2026

RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair.

DNA double-stranded breaks (DSBs) are toxic events that can be reversed without genetic information loss by homology-directed repair (HDR), wherein information is copied from an intact template molecule. Finding a correct template within millions to billions of other DNA bases is termed homology search and is mediated...

Charles D. Yeh, Lilly van de Venn, Susanne Kreutzer et al. · Cell Reports · 0 citations

Open access Sep 2026

Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response.

The DNA damage response (DDR) is a sophisticated network of cellular pathways whose perturbation leads to genome instability and is a key hallmark of oncogenesis. Here, we present data from 32 genome-scale loss-of-function CRISPR interference chemical-genetic screens with inhibitors targeting core constituents of the D...

T. O'Loughlin, A. Arab, Sara Misiukiewicz et al. · Nature Chemical Biology · 0 citations