Open access
Jan 2026
Structural Genomics Defines PBRM1 Bromodomain Variant Function in ccRCC
An integrated structural genomics analysis accelerates mechanistic understanding of how ccRCC missense variants impact PBRM1 bromodomain structure and function and supports future studies correlating specific missense variants with PBRM1 tumor‐suppressive functions and patient responses to antiangiogenics and immune ch...
Karina L. Bursch, Salomão D Jorge, A. Catlin et al.
· Human Mutation · 0 citations