During respiratory virus infection, CD8+ T cells kill infected cells and establish antigen-specific memory, but mechanisms regulating these functions remain incompletely understood. Here, we identify mitochondrial transcription factor A (TFAM)-dependent mitochondrial fitness as a regulator of CD8+ T cell function durin...
Z. Navaeiseddighi, Kai Guo, S. Hasan et al.· bioRxiv· 0 citations
Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key effector of the noncanonical inflammasome, has been shown to mediate an inn...
M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham et al.· JCI Insight· 0 citations
ABSTRACT Cells detect invading viruses and produce type I interferons (IFNs) to stimulate an innate antiviral effector response. However, IFN levels must be fine-tuned to achieve antiviral efficacy while limiting hyperinflammatory and tissue-damaging effects. Here, we report that NAT10, a histone and cytidine acetyltra...
Youngmin Park, Yan Liu, Jinshan He et al.· mBio· 0 citations
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