Open access
Aug 2026
Histone H3K27M variants determine myeloid subset dependencies and immune reprogramming in diffuse midline glioma.
Diffuse midline gliomas (DMGs) are highly aggressive, WHO grade 4 glial tumors that arise in midline central nervous system structures and are defined by K27M mutations in histone H3 genes. These K27M mutations shape intratumoral myeloid cell composition in DMG. In H3.1K27M DMGs, genetic ablation of monocyte recruitmen...
Montserrat Puigdelloses Vallcorba, K. Rawat, N. Soni et al.
· Proceedings of the National... · 0 citations