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Jade Wilson

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Open access Oct 2026

An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.

MYC amplification is common and often extrachromosomal (ecDNA) in cancer. To define how MYC DNA copy gains arise from diploid genomes, we assessed whether epigenetic enzymes directly control focal MYC over-replication and amplification. We demonstrate that H3K4 methylation primes MYC for amplification by the H3K9/K36 t...

Benjamin Ferman, Chloe Azadegan, John Santoro et al. · 0 citations

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