Jae-Seung Chung

Abstract B050: Deciphering Rare Patterns of Dual Drug Resistance in metastatic castration resistant prostate cancer through Machine Learning–Based ctDNA Methylation and CTC Transcriptomics

Machine learning–based ctDNA methylation profiling identifies a clinically actionable molecular signature associated with rare dual-resistance phenotypes in advanced prostate cancer, which suggests a rare epithelial-fixed, AR-reinforced phenotype that evades conventional therapeutic pressure through epigenetic stabiliz...