Jakub Cervinka

Mitochondria-Disrupting Aminocarbyne−DMAP Diiron(I) Complexes Perturb Iron Homeostasis with Marginal ROS Contribution in Cancer Cells

Five diiron complexes, [Fe2Cp2(CO)(dmap)(μ-CO){μ-CN(Me)(R)}]CF3SO3 (3a-e), were synthesized from readily available tris-carbonyl precursors and characterized. The complexes display ≈10−4 M aqueous solubility, amphiphilicity, and 50−74% of intact complex remaining after 72 h in DMEM-d/CD3OD solution. All compounds exh...