James Byrnes

Virulence gene regulation in Pseudomonas aeruginosa is mediated by a novel hinge motion in the signaling helix of GacS histidine kinase.

Sensor kinases (SKs) play central roles in bacterial adaptation to environmental challenges. Signal perception by these membrane-embedded enzymes initiates phosphotransfer cascades that regulate gene expression through cognate transcription factors. Although SKs were thought to function independently, interwoven multi-...