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Author

James F. Martin

2 papers indexed here

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Open access Sep 2026

PITX2 missense coding variant expression in mice reveals direct function in atrial fibrillation.

Atrial fibrillation (AF) is the most common sustained human cardiac arrhythmia and linked to a drastic increase in stroke and heart failure risk. While sequence variations in the PITX2 non-coding region are the strongest genetic signature of AF risk, the direct role of PITX2 in AF remains a topic of debate. Here, we ge...

Jeffrey D. Steimle, Yue Yuan, Shao-Hai Fang et al. · 0 citations
Open access Sep 2026

A metabolic–epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition

Cardiac regeneration is limited in the adult mammalian heart because of restricted cardiomyocyte proliferation and persistent fibrosis. We previously demonstrated that transient pharmacological inhibition of succinate dehydrogenase (SDH) with malonate promotes regeneration after myocardial infarction. Here, we integrat...

Yi Fan, Dakota J. Nuttall, Yi Zhao et al. · 0 citations

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