Open access
Aug 2026
A cholinergic hub in the nucleus accumbens gates opioid-reward learning
Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing analgesia and decouples morphine-evoked dopamine elevations from acetylcholine dips, suggesting pro-cholinergic strategies to limit early opioid reward acquisition.
S. Yousefzadeh, Hai-Dun Yan, Seung-Hwa Kwak et al.
· Nature · 2 citations