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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

James Spencer

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3 papers indexed here

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Open access Oct 2026

Hydration Changes are Essential for Efficient Breakdown of Faropenem by the L1 Metallo-β-lactamase

Metallo-β-lactamases (MBLs) are key contributors to antimicrobial resistance (AMR). The L1 MBL, originally from Stenotrophomonas maltophilia, is a tetrameric, dizinc, subclass B3 MBL that efficiently hydrolyzes most β-lactam antibiotics and evades inhibitors that act on other MBLs. Using quantum mechanics/molecular m...

Papu Kalita, Carlos A. Ramos-Guzmán, Marko Hanževački et al. · 0 citations
Open access Sep 2026

A transition state-like acylenzyme conformation distinguishes carbapenemase activity in class A β-lactamases

Carbapenems are the most potent β-lactams, key antibiotics for healthcare-associated infections by Gram-negative bacteria and evade hydrolysis by most β-lactamases; but are increasingly threatened by emergence of enzymes exhibiting hydrolytic activity towards them. Of the four recognised β-lactamase subclasses, class A...

Michael Beer, James Spencer, Adrian J. Mulholland · 0 citations
Open access Aug 2026

Strained alkyne functionalization of carbon dots enables selective photodynamic killing of Gram-positive bacteria

These findings establish strained-alkyne surface engineering as a powerful and modular strategy for imparting photodynamic functionality to carbon nanomaterials, advancing next-generation antimicrobial and antibiofilm technologies.

Cristina Santi, A. Eley, Yuiko Takebayashi et al. · 0 citations

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