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Author

Janet M. Young

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Open access Sep 2026

The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and behavior of their reconstructed ancestors

Abstract Homing endonucleases (HEs) are selfish genetic elements that drive the mobilization of their own coding sequences, often in concert with surrounding introns. Homing endonuclease genes (HEGs) usually display life cycles in which they accumulate inactivating mutations after invading a host genomic target site, l...

Janet M. Young, A. Lambert, Janet M. Young et al. · 0 citations
Open access Aug 2026

Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulation

It is shown that ACTL8 surprisingly localizes to the nucleus of spermatogonia in human testes and breast and lung cancer cells, and Mechanistically, it is found that ACTL8 interacts with KDM5B, an H3K4 demethylase and transcriptional repressor, and this interaction contributes to changes in migration.

Nuria Cortes-Silva, Sanjana Banerjee, Kristen Dominique Amarillo et al. · 0 citations

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