Open access
Sep 2026
Aβ-42 Side Chain Deamidation at Q15 or N27 Modulates Protein Aggregation and Alters Microglial Cytokines and CD68
The progressive aggregation of amyloid beta (Aβ) monomers into oligomers is a critical factor in Alzheimer’s disease (AD) pathogenesis. Although mutated forms of Aβ have been shown to display altered aggregation dynamics, the specific effects of deamidated Aβ on microglial function remain understudied. Our research g...
Martin N. Griffin, Daniel M. Dinakarapandian, Chen-Xing Li et al.
· ACS Chemical Neuroscience · 0 citations