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Author

Janosch Hennig

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Open access Aug 2026

Transient interdomain interactions shape the conformational ensemble governing RNA recognition by the tandem RRMs of Sex-lethal

It is demonstrated that RNA recognition by Sxl is governed not by a single apo structure but by a finely balanced conformational ensemble, and that perturbing this equilibrium in either direction compromises high-affinity and sequence-selective RNA binding.

Julia Meyer, Kristian Schweimer, P. Matzner et al. · 0 citations
Review Open access Jul 2026

Integrative structural biology of protein-RNA interactions in four dimensions.

Recent developments in integrative modeling of protein-RNA complexes are reviewed, highlighting advances in in-cell, 4D and condensate structural biology, and how these approaches shape the understanding of RNP assembly, regulation, and function in physiologically relevant environments are discussed.

S. Heber, Janosch Hennig · 1 citation

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