Jareb J. Pérez-Caraballo

SERPINB1 as a critical regulator of inflammation and protease activity in human monocytic cells

Abstract SERPINB1, a member of the serpin superfamily, functions primarily as a serine protease suicide inhibitor via its reactive center loop (RCL). While murine studies have elucidated its role in neutrophil homeostasis and survival, the functions and pathways orchestrated by human SERPINB1, particularly in monocytes...